Intracranial atherosclerosis

Adnan I. Qureshi, Louis R. Caplan

Research output: Contribution to journalArticlepeer-review

162 Scopus citations

Abstract

Atherosclerotic disease often involves the intracranial arteries including those encased by cranial bones and dura, and those located in the subarachnoid space. Age, hypertension, and diabetes mellitus are independent risk factors for intracranial atherosclerosis. Intracranial atherosclerosis can result in thromboembolism with or without hypoperfusion leading to transient or permanent cerebral ischaemic events. High rates of recurrent ischaemic stroke and other cardiovascular events mandate early diagnosis and treatment. Present treat ment is based on a combination of antiplatelet drugs, optimisation of blood pressure and LDL cholesterol values, and intracranial angioplasty or stent placement, or both, in selected patients.

Original languageEnglish (US)
Pages (from-to)984-998
Number of pages15
JournalThe Lancet
Volume383
Issue number9921
DOIs
StatePublished - Jan 1 2014

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