Intracranial aneurysms: Review of current treatment options and outcomes

Brad Seibert, Ramachandra P. Tummala, Ricky Chow, Alireza Faridar, Seyed A. Mousavi, Afshin A. Divani

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Intracranial aneurysms are present in roughly 5% of the population, yet most are often asymptomatic and never detected. Development of an aneurysm typically occurs during adulthood, while formation and growth are associated with risk factors such as age, hyper-tension, pre-existing familial conditions, and smoking. Subarachnoid hemorrhage, the most common presentation due to aneurysm rupture, represents a serious medical condition often leading to severe neurological deficit or death. Recent technological advances in imag-ing modalities, along with increased understanding of natural history and prevalence of aneurysms, have increased detection of asymptomatic unruptured intracranial aneurysms (UIA). Studies reporting on the risk of rupture and outcomes have provided much insight, but the debate remains of how and when unruptured aneurysms should be managed. Treatment methods include two major intervention options: clipping of the aneurysm and endovascular methods such as coiling, stent-assisted coiling, and flow diversion stents. The studies reviewed here support the generalized notion that endovascular treatment of UIA provides a safe and effective alternative to surgical treatment.The risks associated with endovascular repair are lower and incur shorter hospital stays for appropriately selected patients. The endovascular treatment option should be considered based on factors such as aneurysm size, location, patient medical history, and operator experience.

Original languageEnglish (US)
Article numberArticle 40
JournalFrontiers in Neurology
VolumeJUL
DOIs
StatePublished - 2011

Keywords

  • Aneurysms
  • Clipping
  • Coiling
  • Endovascular surgery
  • Flow diversion
  • Stents
  • Subarachnoid hemorrhage

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