Intracerebral Malignant Plasmacytoma in a Mule Deer (Odocoileus hemionus)

C. S. Clancy, A. Roug, A. G. Armien, A. J. van Wettere

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1 Scopus citations


A wild, mature, gravid female mule deer (Odocoileus hemionus) was presented with marked neurological signs, including abnormal behaviour, circling and incoordination. The animal was humanely destroyed and submitted for diagnostic investigation. Grossly, a well-demarcated, 3 × 3 × 3 cm intracranial mass replaced the left olfactory bulb and frontal lobe. Histologically, there was a highly cellular, infiltrative and unencapsulated neoplastic mass of round cells with eccentrically located nuclei. Neoplastic cells were immunohistochemically labelled for lambda immunoglobulin light chain. Clusters of CD20- and CD79a-positive cells were scattered throughout the tumour and CD3- and Iba1-positive cells diffusely infiltrated the neoplasm. Ultrastructurally, the cytoplasm of the neoplastic cells had prominent rough endoplasmic reticulum with a variable degree of dilation. Histopathological, immunohistochemical and electron microscopical results were diagnostic for a solitary extramedullary plasmacytoma. Intracranial neoplasms are rarely diagnosed in wildlife species, but they should be included in the differential diagnosis for potential causes of central nervous system disease.

Original languageEnglish (US)
Pages (from-to)268-271
Number of pages4
JournalJournal of Comparative Pathology
Issue number2-3
StatePublished - Feb 1 2016


  • Intracerebral
  • Mule deer
  • Plasmacytoma

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