Intracerebral hemorrhage

A review of coagulation function

Tenbit Emiru, Eric M. Bershad, Nicole D Zantek, Yvonne H Datta, Gundu H.R. Rao, Eliza W. Hartley, Afshin A Divani

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Intracerebral hemorrhage (ICH) is associated with a higher mortality rate among stroke subtypes. The amount of hematoma at baseline and subsequent expansion are considered strong independent markers for determining poor clinical outcome. Even though reduction in blood pressure to prevent and control the amount of bleeding in ICH has received considerable amount of attention, the impact of coagulopathy and platelet dysfunction, on the bleeding diathesis has not been extensively investigated. With the increasing use of antiplatelets and/or anticoagulants, given the aging population, a deeper understanding of the interactions between ICH and hemostatic mechanisms is essential to help minimize the risk of a catastrophic coagulopathy-related ICH. In this review article, etiology and risk factors associated with coagulopathy-related ICH are discussed. An overview of coagulation abnormalities, hemostatic agents, and blood biomarkers pertaining to ICH is included.

Original languageEnglish (US)
Pages (from-to)652-662
Number of pages11
JournalClinical and Applied Thrombosis/Hemostasis
Volume19
Issue number6
DOIs
StatePublished - Nov 1 2013

Fingerprint

Cerebral Hemorrhage
Hemostatics
Hemorrhage
Disease Susceptibility
Hematoma
Anticoagulants
Blood Platelets
Biomarkers
Stroke
Blood Pressure
Mortality
Population

Keywords

  • bleeding diathesis
  • clinical outcome
  • hematoma expansion
  • intracerebral hemorrhage
  • platelet dysfunction

Cite this

Intracerebral hemorrhage : A review of coagulation function. / Emiru, Tenbit; Bershad, Eric M.; Zantek, Nicole D; Datta, Yvonne H; Rao, Gundu H.R.; Hartley, Eliza W.; Divani, Afshin A.

In: Clinical and Applied Thrombosis/Hemostasis, Vol. 19, No. 6, 01.11.2013, p. 652-662.

Research output: Contribution to journalArticle

Emiru, Tenbit ; Bershad, Eric M. ; Zantek, Nicole D ; Datta, Yvonne H ; Rao, Gundu H.R. ; Hartley, Eliza W. ; Divani, Afshin A. / Intracerebral hemorrhage : A review of coagulation function. In: Clinical and Applied Thrombosis/Hemostasis. 2013 ; Vol. 19, No. 6. pp. 652-662.
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