TY - JOUR
T1 - Into the depths of ataxia
AU - Orr, Harry T.
PY - 2004/2
Y1 - 2004/2
N2 - Ataxia is a lethal neurological disease characterized by incoordination, postural abnormalities, difficulties with gait, and problems with clarity of speech. The etiology of ataxia is divided equally between hereditary and sporadic forms. Regardless of cause, the cerebellar cortex is often a target in ataxia. Thus, how a disruption in cerebellar cortex might lead to ataxia is of considerable interest. A report in this issue of the JCI links ataxia to enhanced hyperexcitability of neurons in the deep cerebellar nuclei (see the related article on page 582).
AB - Ataxia is a lethal neurological disease characterized by incoordination, postural abnormalities, difficulties with gait, and problems with clarity of speech. The etiology of ataxia is divided equally between hereditary and sporadic forms. Regardless of cause, the cerebellar cortex is often a target in ataxia. Thus, how a disruption in cerebellar cortex might lead to ataxia is of considerable interest. A report in this issue of the JCI links ataxia to enhanced hyperexcitability of neurons in the deep cerebellar nuclei (see the related article on page 582).
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U2 - 10.1172/JCI200421092
DO - 10.1172/JCI200421092
M3 - Review article
C2 - 14966557
AN - SCOPUS:1642295077
SN - 0021-9738
VL - 113
SP - 505
EP - 507
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 4
ER -