Into the depths of ataxia

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Ataxia is a lethal neurological disease characterized by incoordination, postural abnormalities, difficulties with gait, and problems with clarity of speech. The etiology of ataxia is divided equally between hereditary and sporadic forms. Regardless of cause, the cerebellar cortex is often a target in ataxia. Thus, how a disruption in cerebellar cortex might lead to ataxia is of considerable interest. A report in this issue of the JCI links ataxia to enhanced hyperexcitability of neurons in the deep cerebellar nuclei (see the related article on page 582).

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalJournal of Clinical Investigation
Volume113
Issue number4
DOIs
StatePublished - Feb 2004

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