Intestinal Phosphorus Absorption in Chronic Kidney Disease

Elizabeth R Stremke, Kathleen M Hill Gallant

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Chronic kidney disease (CKD) affects approximately 10% of adults worldwide. Dysregulation of phosphorus homeostasis which occurs in CKD leads to development of CKD-Mineral Bone Disorder (CKD-MBD) and contributes to increased morbidity and mortality in these patients. Phosphorus is regulated by multiple hormones (parathyroid hormone (PTH), 1,25-dihyxdroxyvitamin D (1,25D), and fibroblast growth factor 23 (FGF23)) and tissues (kidney, intestine, parathyroid glands, and bone) to maintain homeostasis. In health, the kidneys are the major site of regulation for phosphorus homeostasis. However, as kidney function declines, the ability of the kidneys to adequately excrete phosphorus is reduced. The hormonal changes that occur with CKD would suggest that the intestine should compensate for impaired renal phosphorus excretion by reducing fractional intestinal phosphorus absorption. However, limited studies in CKD animal models and patients with CKD suggest that there may be a break in this homeostatic response where the intestine fails to compensate. As many existing therapies for phosphate management in CKD are aimed at reducing absolute intestinal phosphorus absorption, better understanding of the factors that influence fractional and absolute absorption, the mechanism by which intestinal phosphate absorption occurs, and how CKD modifies these is a much-needed area of study.

Original languageEnglish (US)
JournalNutrients
Volume10
Issue number10
DOIs
StatePublished - Sep 23 2018
Externally publishedYes

Keywords

  • Animals
  • Bone Density
  • Bone Diseases/etiology
  • Fibroblast Growth Factors/blood
  • Homeostasis
  • Humans
  • Intestinal Absorption
  • Intestines/physiology
  • Kidney/metabolism
  • Malabsorption Syndromes/etiology
  • Parathyroid Hormone/blood
  • Phosphorus/metabolism
  • Phosphorus, Dietary/metabolism
  • Renal Insufficiency, Chronic/complications
  • Vitamin D/analogs & derivatives

PubMed: MeSH publication types

  • Journal Article
  • Review

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