Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease

Alexa R. Weingarden, Byron P. Vaughn

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Inflammatory bowel disease (IBD) is a complex set of diseases that lead to chronic inflammation in the gastrointestinal tract. Although the etiology of IBD is not fully understood, it is well-known that the intestinal microbiota is associated with the development and maintenance of IBD. Manipulation of the gut microbiota, therefore, may represent a target for IBD therapy. Fecal microbiota transplantation (FMT), where fecal microbiota from a healthy donor is transplanted into a patient's GI tract, is already a successful therapy for Clostridium difficile infection. FMT is currently being explored as a potential therapy for IBD as well. In this review, the associations between the gut microbiota and IBD and the emerging data on FMT for IBD will be discussed.

Original languageEnglish (US)
Pages (from-to)238-252
Number of pages15
JournalGut microbes
Volume8
Issue number3
DOIs
StatePublished - May 4 2017

Keywords

  • Crohn's disease
  • Inflammatory Bowel Disease
  • fecal microbiota transplant
  • ulcerative colitis

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