Interweaving the strands: β-catenin, an HIV Co-receptor, and schwann cell tumors

David Largaespada, Nancy Ratner

Research output: Contribution to journalShort survey

8 Scopus citations

Abstract

WNT/β-catenin signaling is critical to the development of many cancer types. A paper by Mo and colleagues in a recent issue of Cell shows that autocrine CXCL12/CXCR4 chemokine signaling activates β-catenin signaling in a rare peripheral nerve sarcoma. Together with the availability of small molecules targeting CXCR4, this finding suggests new avenues for cancer therapy.

Original languageEnglish (US)
Pages (from-to)269-271
Number of pages3
JournalCancer Cell
Volume23
Issue number3
DOIs
StatePublished - Mar 18 2013

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