This is the protocol for a review and there is no abstract. The objectives are as follows: Our objective is to evaluate the effectiveness of educational or policy interventions in research integrity or responsible conduct of research on the behaviour and attitudes of researchers in health and other research areas. Since serious research and publication misconduct is relatively rare, and interventions may be designed to have long-term effects, the effects of interventions on the frequency of research misconduct are hard to measure. Therefore surrogate endpoints such as researcher attitudes also need to be considered. In this review we will particularly focus on interventions aimed at fostering research integrity, which views research behaviour from the perspective of professional standards (Steneck 2006). The review will also explore interventions to prevent unacceptable or fraudulent research and publication practices.