Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

Emily A. Thompson, Jason S. Mitchell, Lalit K. Beura, David J. Torres, Paulus Mrass, Mark J. Pierson, Judy L. Cannon, David Masopust, Brian T. Fife, Vaiva Vezys

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Using in vivo imaging of pathogen- and self-specific CD8 T cells in the small intestine, Thompson et al. reveal dynamic changes in the speed and volume of tissue surveyed by CD8 T cells over time after antigen encounter. Migration was CD103 independent, and motility was most limited during the memory response.

Original languageEnglish (US)
Pages (from-to)2859-2867.e4
JournalCell reports
Volume26
Issue number11
DOIs
StatePublished - Mar 12 2019

Keywords

  • 2-photon microscopy
  • CD8 T cells
  • T cell migration
  • immune surveillance
  • integrins
  • mathematical modeling
  • motility
  • mucosal immunity
  • resident memory T cells
  • tolerance

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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