Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

Robert J. Turesky; Anne Constable; Laurent B. Fay; F. Peter Guengerich

doi:10.1016/S0304-3835(99)00137-8

Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

Robert J. Turesky, Anne Constable, Laurent B. Fay, F. Peter Guengerich

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The catalytic efficiences of cytochrome P450 (P450)-mediated N-oxidation of the 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by recombinant human P450 1A2 were 10-19-fold higher than rat P450 1A2, while methoxyresorufin O-demethylation activity was comparable for both P450s. Similar findings were observed with rat and human liver microsomal samples. Interspecies differences in P450 enzyme expression and catalytic activities may be significant and must be considered when assessing human health risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	109-112
Number of pages	4
Journal	Cancer Letters
Volume	143
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(99)00137-8
State	Published - Sep 1999

Bibliographical note

Funding Information:
This work was supported in part by United States Public Health Service Grant R35 CA44353 and P30 ESOO267

Keywords

Cytochrome P450
Food carcinogens
Hetercyclic aromatic amines (HAAs)
Interspecies comparisons
N-oxidation

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(99)00137-8

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title = "Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2",

abstract = "The catalytic efficiences of cytochrome P450 (P450)-mediated N-oxidation of the 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by recombinant human P450 1A2 were 10-19-fold higher than rat P450 1A2, while methoxyresorufin O-demethylation activity was comparable for both P450s. Similar findings were observed with rat and human liver microsomal samples. Interspecies differences in P450 enzyme expression and catalytic activities may be significant and must be considered when assessing human health risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Cytochrome P450, Food carcinogens, Hetercyclic aromatic amines (HAAs), Interspecies comparisons, N-oxidation",

author = "Turesky, {Robert J.} and Anne Constable and Fay, {Laurent B.} and Guengerich, {F. Peter}",

note = "Funding Information: This work was supported in part by United States Public Health Service Grant R35 CA44353 and P30 ESOO267",

year = "1999",

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doi = "10.1016/S0304-3835(99)00137-8",

language = "English (US)",

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T1 - Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

AU - Turesky, Robert J.

AU - Constable, Anne

AU - Fay, Laurent B.

AU - Guengerich, F. Peter

N1 - Funding Information: This work was supported in part by United States Public Health Service Grant R35 CA44353 and P30 ESOO267

PY - 1999/9

Y1 - 1999/9

N2 - The catalytic efficiences of cytochrome P450 (P450)-mediated N-oxidation of the 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by recombinant human P450 1A2 were 10-19-fold higher than rat P450 1A2, while methoxyresorufin O-demethylation activity was comparable for both P450s. Similar findings were observed with rat and human liver microsomal samples. Interspecies differences in P450 enzyme expression and catalytic activities may be significant and must be considered when assessing human health risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - The catalytic efficiences of cytochrome P450 (P450)-mediated N-oxidation of the 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by recombinant human P450 1A2 were 10-19-fold higher than rat P450 1A2, while methoxyresorufin O-demethylation activity was comparable for both P450s. Similar findings were observed with rat and human liver microsomal samples. Interspecies differences in P450 enzyme expression and catalytic activities may be significant and must be considered when assessing human health risk. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - Cytochrome P450

KW - Food carcinogens

KW - Hetercyclic aromatic amines (HAAs)

KW - Interspecies comparisons

KW - N-oxidation

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DO - 10.1016/S0304-3835(99)00137-8

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AN - SCOPUS:0032806625

SN - 0304-3835

VL - 143

SP - 109

EP - 112

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

Abstract

Bibliographical note

Keywords

UN SDGs

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