Interspecies conservation and variation in peptidergic neurons

Robert Elde, Suzanne Haber, Raymond Ho, Vicky Holets, Nihal de Lanerolle, Bruce Maley, Paul Micevych, Virginia Seybold

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The degree of variation in structure of neurohypophyseal nonapeptides is reviewed and contrasted with the striking conservation in the structure of somatostatin across a range of vertebrate phylogeny. The distribution of neuropeptides has been most thoroughly studied in the central nervous system of the rat. Preliminary interspecies comparisons of the distribution of neuropeptides suggest that certain peptidergic elements found to be abundant in some species are poorly represented in the rat. Other peptidergic elements seem not to vary significantly between species.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
Issue numberSUPPL. 1
StatePublished - 1980

Bibliographical note

Funding Information:
Studies from the authors' laboratories have been supported by grants from the Graduate School, University of Minnesota, the 3M Foundation, and NIDA (DA02148). S. H. and V. S. are the recipients of Fellowships in Pharmacology/Morphology from the Pharmaceutical Manufacturers Association. R. E. is the recipient of a Scholars in Neuroscience Award from the McKnight Foundation.


  • Adrenal chromaffin cells
  • Endocrine pancreas
  • Enkephalins
  • Globus pallidus
  • Hypothalamic median eminence
  • Immunohistochemistry
  • Neuropeptides
  • Neurotensin
  • Oxytocin
  • Primary afferent neurons
  • Somatostatin
  • Substance P
  • Substantia gelatinosa
  • Vasopressin


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