The degree of variation in structure of neurohypophyseal nonapeptides is reviewed and contrasted with the striking conservation in the structure of somatostatin across a range of vertebrate phylogeny. The distribution of neuropeptides has been most thoroughly studied in the central nervous system of the rat. Preliminary interspecies comparisons of the distribution of neuropeptides suggest that certain peptidergic elements found to be abundant in some species are poorly represented in the rat. Other peptidergic elements seem not to vary significantly between species.
Bibliographical noteFunding Information:
Studies from the authors' laboratories have been supported by grants from the Graduate School, University of Minnesota, the 3M Foundation, and NIDA (DA02148). S. H. and V. S. are the recipients of Fellowships in Pharmacology/Morphology from the Pharmaceutical Manufacturers Association. R. E. is the recipient of a Scholars in Neuroscience Award from the McKnight Foundation.
Copyright 2014 Elsevier B.V., All rights reserved.
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