Abstract
Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.
Original language | English (US) |
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Pages (from-to) | 1838-1844 |
Number of pages | 7 |
Journal | Experimental Biology and Medicine |
Volume | 246 |
Issue number | 16 |
Early online date | Jun 24 2021 |
DOIs | |
State | Published - Aug 2021 |
Bibliographical note
Funding Information:The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the National Institutes of Health [HL144582] and the Department of Defense [grant numbers W81XWH2020047, W81XWH2020048 and W81WH1910610].
Publisher Copyright:
© 2021 by the Society for Experimental Biology and Medicine.
Keywords
- Chimera
- ETV2
- MYF5
- MYF6
- MYOD
- hiPSCs
- somatic cell nuclear transfer