Interspecies chimeras as a platform for exogenic organ production and transplantation

Daniel J. Garry; Mary G. Garry

doi:10.1177/15353702211024948

Interspecies chimeras as a platform for exogenic organ production and transplantation

Daniel J. Garry, Mary G. Garry

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

Original language	English (US)
Pages (from-to)	1838-1844
Number of pages	7
Journal	Experimental Biology and Medicine
Volume	246
Issue number	16
Early online date	Jun 24 2021
DOIs	https://doi.org/10.1177/15353702211024948
State	Published - Aug 2021

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This work was supported by the National Institutes of Health [HL144582] and the Department of Defense [grant numbers W81XWH2020047, W81XWH2020048 and W81WH1910610].

Publisher Copyright:
© 2021 by the Society for Experimental Biology and Medicine.

Keywords

Chimera
ETV2
MYF5
MYF6
MYOD
hiPSCs
somatic cell nuclear transfer

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10.1177/15353702211024948

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abstract = "Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.",

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AU - Garry, Mary G.

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AB - Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

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Interspecies chimeras as a platform for exogenic organ production and transplantation

Abstract

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Keywords

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