Interspecies chimeras as a platform for exogenic organ production and transplantation

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Abstract

Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

Original languageEnglish (US)
Pages (from-to)1838-1844
Number of pages7
JournalExperimental Biology and Medicine
Volume246
Issue number16
Early online dateJun 24 2021
DOIs
StatePublished - Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 by the Society for Experimental Biology and Medicine.

Keywords

  • Chimera
  • ETV2
  • MYF5
  • MYF6
  • MYOD
  • hiPSCs
  • somatic cell nuclear transfer

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