International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

Kaspar Matiasek, Martí Pumarola i Batlle, Marco Rosati, Francisco Fernández-Flores, Andrea Fischer, Eva Wagner, Mette Berendt, Sofie F M Bhatti, Luisa De Risio, Robyn G. Farquhar, Sam Long, Karen Muñana, Edward E. Patterson, Akos Pakozdy, Jacques Penderis, Simon Platt, Michael Podell, Heidrun Potschka, Clare Rusbridge, Veronika M. SteinAndrea Tipold, Holger A. Volk

Research output: Contribution to journalLetterpeer-review

13 Scopus citations

Abstract

Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals. The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures. Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements. The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations.

Original languageEnglish (US)
Article number216
JournalBMC Veterinary Research
Volume11
Issue number1
DOIs
StatePublished - Aug 28 2015

Keywords

  • Canine
  • Epileptogenic
  • Feline
  • Hippocampus
  • Ictogenic
  • Neuropathology
  • Processing
  • Seizures

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