International trends in incidence of osteosarcoma (1988-2012)

Gabriela A. Rojas, Aubrey K Hubbard, Brandon J. Diessner, Karina B. Ribeiro, Logan G. Spector

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. The etiology of OS is largely unknown but may be informed by comparisons of incidence and trends between geographic regions. Using the Cancer Incidence in Five Continents (CI5) data from 1988 to 2012, we present OS age-standardized incidence rates (ASRs; cases/million) and average annual percent change (AAPC) and 95% confidence interval (CI) by geographic region among the age groups 0-9, 10-19, 20-29, 30-59, 60-79, 0-79. Among the 10-19 age group, we also used the most recent data (2008-2012) to present the ASRs for each country. We observed little variation in OS incidence between geographic regions in 2008-2012 across all age groups. Overall, the ASR for 0-79 ranged from 2 cases per million in Southern Asia to 4.2 in Sub-Saharan Africa. A bimodal distribution in incidence was observed with peaks in the 10-19 and 60-79 age groups across all regions over time. Overall, OS incidence was relatively stable across 1988-2012 with the only statistically significant increases in the 0-79 age group observed in Eastern Asia (AAPC: 1.8; 95% CI: 0.6, 1.9) and Sub-Saharan Africa (AAPC: 3.1; 95% CI: 0.5, 5.8). The small variation in incidence between regions and the stability in incidence over time suggests that OS carcinogenesis is not influenced by environmental or time-varying exposures.

Original languageEnglish (US)
Pages (from-to)1044-1053
Number of pages10
JournalInternational Journal of Cancer
Issue number5
Early online dateMay 8 2021
StatePublished - Sep 1 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (T32 CA099936 to Aubrey K. Hubbard).

Publisher Copyright:
© 2021 UICC.


  • bone cancer
  • epidemiology
  • incidence
  • international
  • osteosarcoma


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