Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults)

James G. Terry; Christina M. Shay; Pamela J. Schreiner; David R. Jacobs; Otto A. Sanchez; Jared P. Reis; David C. Goff; Samuel S. Gidding; Lyn M. Steffen; John Jeffrey Carr

doi:10.1161/ATVBAHA.117.309633

Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults)

James G. Terry, Christina M. Shay, Pamela J. Schreiner, David R. Jacobs, Otto A. Sanchez, Jared P. Reis, David C. Goff, Samuel S. Gidding, Lyn M. Steffen, John Jeffrey Carr

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Objective-Excess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants. Approach and Results-We measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models. Conclusions-In a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots.

Original language	English (US)
Pages (from-to)	2370-2378
Number of pages	9
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	37
Issue number	12
DOIs	https://doi.org/10.1161/ATVBAHA.117.309633
State	Published - 2017

Bibliographical note

Funding Information:
The CARDIA study (Coronary Artery Risk Development in Young Adults) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C and HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C), Johns Hopkins University School of Medicine (HHSN268200900041C), and Vanderbilt School of Medicine (R01-HL098445). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005).

Publisher Copyright:
© 2017 American Heart Association, Inc.

Keywords

Adipose tissue
Body mass index
Muscle
Prevalence
Risk factors
Vascular calcification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/ATVBAHA.117.309633

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699947

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Terry, J. G., Shay, C. M., Schreiner, P. J., Jacobs, D. R., Sanchez, O. A., Reis, J. P., Goff, D. C., Gidding, S. S., Steffen, L. M., & Carr, J. J. (2017). Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults). Arteriosclerosis, thrombosis, and vascular biology, 37(12), 2370-2378. https://doi.org/10.1161/ATVBAHA.117.309633

Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults). / Terry, James G.; Shay, Christina M.; Schreiner, Pamela J. et al.
In: Arteriosclerosis, thrombosis, and vascular biology, Vol. 37, No. 12, 2017, p. 2370-2378.

Research output: Contribution to journal › Article › peer-review

Terry, JG, Shay, CM, Schreiner, PJ , Jacobs, DR , Sanchez, OA, Reis, JP, Goff, DC, Gidding, SS, Steffen, LM & Carr, JJ 2017, 'Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults)', Arteriosclerosis, thrombosis, and vascular biology, vol. 37, no. 12, pp. 2370-2378. https://doi.org/10.1161/ATVBAHA.117.309633

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title = "Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults)",

abstract = "Objective-Excess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants. Approach and Results-We measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models. Conclusions-In a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots.",

keywords = "Adipose tissue, Body mass index, Muscle, Prevalence, Risk factors, Vascular calcification",

author = "Terry, {James G.} and Shay, {Christina M.} and Schreiner, {Pamela J.} and Jacobs, {David R.} and Sanchez, {Otto A.} and Reis, {Jared P.} and Goff, {David C.} and Gidding, {Samuel S.} and Steffen, {Lyn M.} and Carr, {John Jeffrey}",

note = "Funding Information: The CARDIA study (Coronary Artery Risk Development in Young Adults) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C and HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C), Johns Hopkins University School of Medicine (HHSN268200900041C), and Vanderbilt School of Medicine (R01-HL098445). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). Publisher Copyright: {\textcopyright} 2017 American Heart Association, Inc.",

year = "2017",

doi = "10.1161/ATVBAHA.117.309633",

language = "English (US)",

volume = "37",

pages = "2370--2378",

journal = "Arteriosclerosis, thrombosis, and vascular biology",

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number = "12",

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T1 - Intermuscular adipose tissue and subclinical coronary artery calcification in midlife

T2 - The CARDIA study (coronary artery risk development in young adults)

AU - Terry, James G.

AU - Shay, Christina M.

AU - Schreiner, Pamela J.

AU - Jacobs, David R.

AU - Sanchez, Otto A.

AU - Reis, Jared P.

AU - Goff, David C.

AU - Gidding, Samuel S.

AU - Steffen, Lyn M.

AU - Carr, John Jeffrey

N1 - Funding Information: The CARDIA study (Coronary Artery Risk Development in Young Adults) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201300025C and HHSN268201300026C), Northwestern University (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser Foundation Research Institute (HHSN268201300029C), Johns Hopkins University School of Medicine (HHSN268200900041C), and Vanderbilt School of Medicine (R01-HL098445). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI (AG0005). Publisher Copyright: © 2017 American Heart Association, Inc.

PY - 2017

Y1 - 2017

N2 - Objective-Excess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants. Approach and Results-We measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models. Conclusions-In a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots.

AB - Objective-Excess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants. Approach and Results-We measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models. Conclusions-In a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots.

KW - Adipose tissue

KW - Body mass index

KW - Muscle

KW - Prevalence

KW - Risk factors

KW - Vascular calcification

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Intermuscular adipose tissue and subclinical coronary artery calcification in midlife: The CARDIA study (coronary artery risk development in young adults)

Abstract

Bibliographical note

Keywords

UN SDGs

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