Interleukin-8 in the Tumor Immune Niche: Lessons from Comparative Oncology

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Interleukin (IL)-8 is a chemokine that is essential for inflammation and angiogenesis. IL-8 expression is elevated in tumor cell lines and tissues, as well as in peripheral blood obtained from cancer patients. Primary works have attempted to determine the biological effect of IL-8 on tumor cells, including cell proliferation, survival, and migration. More recently, IL-8 has acquired considerable attention as an immune modulator in the context of certain tumor microenvironments (TME); specifically, it can support a niche that favors tumor progression and metastasis. Tumor-derived IL-8 stimulates inflammation by interacting with the microenvironmental constituents, including fibroblasts, endothelial cells, and immune cells. However, the tumor immune system is complex, and mechanisms that construct the immune phenotype remain incompletely characterized. Herein, we will (1) address a potential role of IL-8 in regulating gene expression to establish immune landscape in tumor. Then, we will (2) review IL-8 signaling in the maintenance of stem cells and regulation of hematopoietic progenitors. Finally, (3) IL-8 functions will be discussed in naturally occurring animal cancers that offer a clinically realistic model for translational research. This chapter will provide a new insight into the tumor immune niche and help us develop immunotherapies for cancers.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages25-33
Number of pages9
DOIs
StatePublished - Jan 1 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1240
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Angiogenesis
  • Canine
  • Comparative oncology
  • Cytokine
  • Hemangiosarcoma
  • Hematopoiesis
  • Immune landscape
  • Immunity
  • Inflammation
  • Interleukin-8
  • Microenvironment
  • Niche
  • Stem cells
  • Tumor

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article
  • Review

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