Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

I. P. Ryan; J. F. Tseng; E. D. Schriock; O. Khorram; D. V. Landers; R. N. Taylor

doi:10.1016/s0015-0282(16)57506-2

Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

I. P. Ryan
, J. F. Tseng
, E. D. Schriock
, O. Khorram
, D. V. Landers
, R. N. Taylor

Obstetrics, Gynecology and Women's Health - Maternal Fetal Medicine

Research output: Contribution to journal › Article › peer-review

226 Scopus citations

Abstract

Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.

Original language	English (US)
Pages (from-to)	929-932
Number of pages	4
Journal	Fertility and Sterility
Volume	63
Issue number	4
DOIs	https://doi.org/10.1016/s0015-0282(16)57506-2
State	Published - 1995

Bibliographical note

Funding Information:
Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).

Keywords

Endometriosis
IL-8
angiogenesis
peritoneal fluid

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10.1016/s0015-0282(16)57506-2

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title = "Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis",

abstract = "Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67\%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.",

keywords = "Endometriosis, IL-8, angiogenesis, peritoneal fluid",

author = "Ryan, \{I. P.\} and Tseng, \{J. F.\} and Schriock, \{E. D.\} and O. Khorram and Landers, \{D. V.\} and Taylor, \{R. N.\}",

note = "Funding Information: Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).",

year = "1995",

doi = "10.1016/s0015-0282(16)57506-2",

language = "English (US)",

volume = "63",

pages = "929--932",

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issn = "0015-0282",

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TY - JOUR

T1 - Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

AU - Ryan, I. P.

AU - Tseng, J. F.

AU - Schriock, E. D.

AU - Khorram, O.

AU - Landers, D. V.

AU - Taylor, R. N.

N1 - Funding Information: Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).

PY - 1995

Y1 - 1995

N2 - Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.

AB - Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.

KW - Endometriosis

KW - IL-8

KW - angiogenesis

KW - peritoneal fluid

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U2 - 10.1016/s0015-0282(16)57506-2

DO - 10.1016/s0015-0282(16)57506-2

M3 - Article

C2 - 7890085

AN - SCOPUS:0028947608

SN - 0015-0282

VL - 63

SP - 929

EP - 932

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

Abstract

Bibliographical note

Keywords

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