Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

I. P. Ryan; J. F. Tseng; E. D. Schriock; O. Khorram; D. V. Landers; R. N. Taylor

doi:10.1016/s0015-0282(16)57506-2

Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

I. P. Ryan, J. F. Tseng, E. D. Schriock, O. Khorram, D. V. Landers, R. N. Taylor

Obstetrics, Gynecology and Women's Health - Fetal Medicine

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.

Original language	English (US)
Pages (from-to)	929-932
Number of pages	4
Journal	Fertility and Sterility
Volume	63
Issue number	4
DOIs	https://doi.org/10.1016/s0015-0282(16)57506-2
State	Published - 1995

Bibliographical note

Funding Information:
Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).

Keywords

Endometriosis
IL-8
angiogenesis
peritoneal fluid

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10.1016/s0015-0282(16)57506-2

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title = "Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis",

abstract = "Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.",

keywords = "Endometriosis, IL-8, angiogenesis, peritoneal fluid",

author = "Ryan, {I. P.} and Tseng, {J. F.} and Schriock, {E. D.} and O. Khorram and Landers, {D. V.} and Taylor, {R. N.}",

note = "Funding Information: Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).",

year = "1995",

doi = "10.1016/s0015-0282(16)57506-2",

language = "English (US)",

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T1 - Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

AU - Ryan, I. P.

AU - Tseng, J. F.

AU - Schriock, E. D.

AU - Khorram, O.

AU - Landers, D. V.

AU - Taylor, R. N.

N1 - Funding Information: Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).

PY - 1995

Y1 - 1995

N2 - Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.

AB - Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.

KW - Endometriosis

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KW - angiogenesis

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ER -

Interleukin-8 concentrations are elevated in peritoneal fluid of women with endometriosis

Abstract

Bibliographical note

Keywords

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