Objective: To investigate the presence of interleukin-8 (IL-8), a macrophage-derived angiogenic factor, in peritoneal fluid (PF) of women with and without endometriosis. Design: Case-control study. Setting: University hospital. Patients: Eighteen women with laparoscopic findings of mild to severe endometriosis, and nine women with no visual evidence of pelvic pathology. Main Outcome Measures: Peritoneal fluid IL-8 levels were determined using an ELISA. Interleukin-8 concentrations were compared among women with and without endometriosis. Correlation between PF IL-8 concentration and endometriosis stage was investigated. Results: Interleukin- 8 was detectable in the PF of a majority of women (67%). Interleukin-8 concentrations were higher in the PF of women with endometriosis than in matched normal controls. A significant correlation between PF IL-8 concentration and endometriosis stage was noted. Conclusions: We hypothesize that IL-8 is an important angiogenic factor that contributes to the pathogenesis of endometriosis by promoting the neovascularization of ectopic endometrial implants.
Bibliographical noteFunding Information:
Received May 23, 1994; revised and accepted November 16, 1994. * Presented at the 41st Annual Meeting of the Society for Gynecologic Investigation, Chicago, Illinois, March 22 to 26, 1994. t Supported in part by the 1992-1993 American Fertility Society-Serono Research Fellowship in Reproductive Medicine, Bir· mingham, Alabama. :j: Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine. § Supported by a Howard Hughes Medical Institute Research Training Fellowship for Medical Students, University of California, San Francisco, California. II Present address: Department of Reproductive Medicine, U niversity of California, San Diego, San Diego, California. 'If Reprint requests: Robert N. Taylor, M.D., Ph.D., Depart· ment of Obstetrics, Gynecology and Reproductive Sciences, U niversity of California, San Francisco, M ·1489, San Francisco, California 94143-0132 (FAX: 415-753-3271).
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