Interleukin-7 is required for CD4+ T cell activation and autoimmune neuroinflammation

Brian R. Lawson, Rosana Gonzalez-Quintial, Theodoros Eleftheriadis, Michael A Farrar, Stephen D. Miller, Karsten Sauer, Dorian B. McGavern, Dwight H. Kono, Roberto Baccala, Argyrios N. Theofilopoulos

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

IL-7 is known to be vital for T cell homeostasis but has previously been presumed to be dispensable for TCR-induced activation. Here, we show that IL-7 is critical for the initial activation of CD4+ T cells in that it provides some of the necessary early signaling components, such as activated STAT5 and Akt. Accordingly, short-term in vivo IL-7Rα blockade inhibited the activation and expansion of autoantigen-specific CD4+ T cells and, when used to treat experimental autoimmune encephalomyelitis (EAE), prevented and ameliorated disease. Our studies demonstrate that IL-7 signaling is a prerequisite for optimal CD4+ T cell activation and that IL-7R antagonism may be effective in treating CD4+ T cell-mediated neuroinflammation and other autoimmune inflammatory conditions.

Original languageEnglish (US)
Pages (from-to)260-269
Number of pages10
JournalClinical Immunology
Volume161
Issue number2
DOIs
StatePublished - Dec 1 2015

Keywords

  • EAE
  • IL-7
  • Signaling pathways
  • T cells

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    Lawson, B. R., Gonzalez-Quintial, R., Eleftheriadis, T., Farrar, M. A., Miller, S. D., Sauer, K., McGavern, D. B., Kono, D. H., Baccala, R., & Theofilopoulos, A. N. (2015). Interleukin-7 is required for CD4+ T cell activation and autoimmune neuroinflammation. Clinical Immunology, 161(2), 260-269. https://doi.org/10.1016/j.clim.2015.08.007