Interleukin-6 and tumor necrosis factor-alpha values in elk neonates

Shannon M. Barber-Meyer, Craig R. Johnson, Michael P. Murtaugh, L. David Mech, P. J. White

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Serological indicators of general condition would be helpful for monitoring or assessing ungulate wildlife. Toward that end, we report the 1st reference values for 2 cytokines, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in neonatal elk (Cervus elaphus). We obtained blood samples from 140 calves ≤ 6 days old in Yellowstone National Park during summer 2003-2005. TL-6 values ranged from 0 to 1.21 pg/ml with a median of 0.03 pg/ml. TNF-α values ranged from 0 to 225.43 pg/ml with a median of 1.85 pg/ml. IL-6 and TNF-α concentrations were not significant predictors of elk calf survival through 21 days. Development of ungulate-based IL-6 and TNF-α assays that provide greater sensitivity than cross-reacting human-based assays could be helpful in monitoring ungulate condition and health status comparisons among herds. Such information could provide indirect assessments of range quality or environmental influences among herds.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalJournal of Mammalogy
Volume88
Issue number2
DOIs
StatePublished - Apr 2007

Keywords

  • Cervus elaphus
  • Cytokine
  • Elk
  • Immunocompetence
  • Interleukin-6
  • Survival
  • Tumor necrosis factor-alpha
  • Yellowstone

Fingerprint Dive into the research topics of 'Interleukin-6 and tumor necrosis factor-alpha values in elk neonates'. Together they form a unique fingerprint.

Cite this