Interleukin-6 and the development of social disruption-induced glucocorticoid resistance

Jennifer L. Stark, Ronit Avitsur, John Hunzeker, David A. Padgett, John F. Sheridan

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Following social disruption (SDR) stress in male mice, corticosterone resistance of splenocytes was accompanied by enhanced LPS-stimulated interleukin (IL)-6 secretion. The present study examined the role of IL-6 in the development of corticosterone resistance. Addition of IL-6 to control splenocyte cultures did not induce corticosterone resistance. SDR also elevated IL-6 in plasma and liver, but not in spleen. IL-6 deficient mice that were exposed to SDR developed glucocorticoid resistance despite the absence of systemic IL-6. These findings suggest that although SDR enhanced IL-6 responses, IL-6 was not essential for the development of stress-induced splenocyte corticosterone resistance.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalJournal of Neuroimmunology
Volume124
Issue number1-2
DOIs
StatePublished - Mar 20 2002

Keywords

  • Corticosterone resistance
  • Lipopolysaccharide
  • Liver
  • Mice
  • Spleen
  • Stress

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