Interleukin-4 prevents mortality from acute but not chronic murine peritonitis and induces an accelerated tumor necrosis factor-α response

R. G. Sawyer, Lynn K. Rosenlof, T. L. Pruett

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Interleukin-4 (IL-4) demonstrates properties in vitro that suggest an anti-inflammatory role in the immune response, one of which is the inhibition of tumor necrosis factor-α (TNF) release. We examined the effects of IL-4 administration on mortality and serum TNF levels in two murine models of peritonitis. Animals infected with intraperitoneal injections of Escherichia coli and Bacteroides fragilis (acute peritonitis) had a decreased mortality and earlier TNF-α peak when pretreated with 5,000 units IL-4. Animals infected with bacteria and a sterile fecal adjuvant (chronic peritonitis) had no alteration in mortality or serum TNF levels (which were consistently low) with IL-4 pretreatment. These data demonstrate that, under some in vivo conditions, IL-4 can significantly ameliorate a septic insult, but this effect appears to be highly model-dependent and not clearly related to its effects on TNF-α.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalEuropean Surgical Research
Volume28
Issue number2
DOIs
StatePublished - Jan 1 1996

Keywords

  • Interleukin-4
  • Peritonitis
  • Tumor necrosis factor

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