Interleukin-1 genotypes and the association between periodontitis and cardiovascular disease

Kenneth S. Kornman, James Pankow, Steven Offenbacher, James Beck, Francesco Di Giovine, Gordon W. Duff

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

An epidemiological association between periodontitis and cardiovascular disease has been reported in multiple studies. Various mechanisms have been proposed as potential explanations for this association, including a common factor that predisposes certain individuals to a hyper-responsive inflammatory response. Variations in the genes that regulate the interleukin-1 (IL-1) response have been associated with both periodontal disease and cardiovascular disease. New data indicate that one pattern of IL-1 genetic polymorphisms, characterized by the IL-1A (+4845) and IL-1B (+3954) markers, is associated with periodontitis but not certain measures of atherosclerosis. Another IL-1 genetic pattern, characterized by the IL-1B (-511) and IL-1RN (+2018) markers, is associated with atherosclerotic plaque formation, as measured by angiography and arterial wall thickness, but not periodontitis. These two patterns also have different functional implications relative to IL-1 biological activity. Studies of IL-1 gene polymorphisms, atherosclerotic plaque instability and cardiovascular clinical events are in progress. Hypothetical models are presented to explain how IL-1 genetic factors may be involved in cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)353-357
Number of pages5
JournalJournal of Periodontal Research
Volume34
Issue number7
DOIs
StatePublished - Oct 1999

Keywords

  • Cardiovascular
  • Genetics
  • Heart
  • IL-1
  • Periodontitis
  • Stroke

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