Interleukin-1 genotypes and the association between periodontitis and cardiovascular disease

Kenneth S. Kornman, James Pankow, Steven Offenbacher, James Beck, Francesco Di Giovine, Gordon W. Duff

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


An epidemiological association between periodontitis and cardiovascular disease has been reported in multiple studies. Various mechanisms have been proposed as potential explanations for this association, including a common factor that predisposes certain individuals to a hyper-responsive inflammatory response. Variations in the genes that regulate the interleukin-1 (IL-1) response have been associated with both periodontal disease and cardiovascular disease. New data indicate that one pattern of IL-1 genetic polymorphisms, characterized by the IL-1A (+4845) and IL-1B (+3954) markers, is associated with periodontitis but not certain measures of atherosclerosis. Another IL-1 genetic pattern, characterized by the IL-1B (-511) and IL-1RN (+2018) markers, is associated with atherosclerotic plaque formation, as measured by angiography and arterial wall thickness, but not periodontitis. These two patterns also have different functional implications relative to IL-1 biological activity. Studies of IL-1 gene polymorphisms, atherosclerotic plaque instability and cardiovascular clinical events are in progress. Hypothetical models are presented to explain how IL-1 genetic factors may be involved in cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)353-357
Number of pages5
JournalJournal of Periodontal Research
Issue number7
StatePublished - Oct 1999


  • Cardiovascular
  • Genetics
  • Heart
  • IL-1
  • Periodontitis
  • Stroke


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