Interleukin-1α-mediated promotion of long-term alloengraftment and short-term neutrophil expansion does not require the presence of either donor or host T cells

Daniel A. Vallera, Patricia A. Taylor, Michael B. Widmer, Bruce R. Blazar

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In earlier studies, we showed that a 14-day continuous subcutaneous infusion of recombinant human interleukin (IL)-1 accelerated neutrophil recovery and enhanced long-term chimerism in a bone marrow (BM) transplant model in which T-cell-depleted BALB/c donor BM was given to irradiated C57BL/6 fully allogeneic recipients. We have extended these studies to a model entirely devoid of donor and host T cells. In the model, donor BALB/c congenic severe combined immunodeficient (C.B-17-scid/scid) BM cells are T cell depleted. The cells are then transplanted into adult irradiated C57BL/6 hosts that have been thymectomized and treated with anti-CD4 and CD8. When IL-1α was delivered subcutaneously using a mini-osmotic pump, it enhanced short-term neutrophil recovery and longer term alloengraftment despite the absence oft cells in the donors and the hosts. Therefore, T cells were not required for the promotional effects of IL-1α on neutrophil recovery and alloengraftment. Studies also showed that the potency of the IL-1α effects was related to the degree of donor cell engraftment, which was related to the irradiation dose and the presence of T cells. We conclude that IL-1α can augment post-BM transplantation hematopoietic recovery and alloengraftment via a T-cell-independent mechanism by favoring donor allogeneic hematopoietic progenitor cell competition over limited numbers of host progenitor cells.

Original languageEnglish (US)
Pages (from-to)636-642
Number of pages7
JournalTransplantation
Volume62
Issue number5
DOIs
StatePublished - Sep 15 1996

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