Interleaved 31P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter–receiver and dynamic B0 shimming

Byeong Y Lee, Xiao-Hong Zhu, Myung Kyun Woo, Gregor Adriany, Scott Schillak, Wei Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In vivo 31P magnetic resonance spectroscopy (MRS) provides a unique tool for the non-invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of 31P spectra and imaging from two distinct human brain regions of interest with dynamic B0 shimming capability. A transistor–transistor logic controller was employed to actively switch the single-channel X-nuclear radiofrequency (RF) transmitter–receiver between two 31P RF surface coils, enabling the interleaved acquisition of two 31P free induction decays (FIDs) from human occipital and frontal lobes within the same repetition time. Linear gradients were incorporated into the RF pulse sequence to perform the first-order dynamic shimming to further improve spectral resolution. The overall results demonstrate that the approach provides a cost-effective and time-efficient solution for reliable 31P MRS measurement of cerebral phosphate metabolites and adenosine triphosphate (ATP) metabolic fluxes from two human brain regions with high detection sensitivity and spectral quality at 7 T. The same design concept can be extended to acquire multiple spectra from more than two brain regions or can be employed for other magnetic resonance applications beyond the 31P spin.

Original languageEnglish (US)
Article numbere3842
JournalNMR in biomedicine
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Magnetic resonance spectroscopy
Occipital Lobe
Frontal Lobe
Brain
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Imaging techniques
Energy Metabolism
Brain Diseases
Spectral resolution
Magnetic resonance
Metabolites
Adenosine Triphosphate
Phosphates
Costs and Cost Analysis
Switches
Fluxes
Controllers
Costs

Keywords

  • dynamic B shimming
  • high-energy phosphorus metabolism
  • human brain
  • in vivo P MRS imaging
  • neuroenergetics

PubMed: MeSH publication types

  • Journal Article

Cite this

@article{d15ee91f29ce483b934375bc5c27baeb,
title = "Interleaved 31P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter–receiver and dynamic B0 shimming",
abstract = "In vivo 31P magnetic resonance spectroscopy (MRS) provides a unique tool for the non-invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of 31P spectra and imaging from two distinct human brain regions of interest with dynamic B0 shimming capability. A transistor–transistor logic controller was employed to actively switch the single-channel X-nuclear radiofrequency (RF) transmitter–receiver between two 31P RF surface coils, enabling the interleaved acquisition of two 31P free induction decays (FIDs) from human occipital and frontal lobes within the same repetition time. Linear gradients were incorporated into the RF pulse sequence to perform the first-order dynamic shimming to further improve spectral resolution. The overall results demonstrate that the approach provides a cost-effective and time-efficient solution for reliable 31P MRS measurement of cerebral phosphate metabolites and adenosine triphosphate (ATP) metabolic fluxes from two human brain regions with high detection sensitivity and spectral quality at 7 T. The same design concept can be extended to acquire multiple spectra from more than two brain regions or can be employed for other magnetic resonance applications beyond the 31P spin.",
keywords = "dynamic B shimming, high-energy phosphorus metabolism, human brain, in vivo P MRS imaging, neuroenergetics",
author = "Lee, {Byeong Y} and Xiao-Hong Zhu and Woo, {Myung Kyun} and Gregor Adriany and Scott Schillak and Wei Chen",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/nbm.3842",
language = "English (US)",
volume = "31",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Interleaved 31P MRS imaging of human frontal and occipital lobes using dual RF coils in combination with single-channel transmitter–receiver and dynamic B0 shimming

AU - Lee, Byeong Y

AU - Zhu, Xiao-Hong

AU - Woo, Myung Kyun

AU - Adriany, Gregor

AU - Schillak, Scott

AU - Chen, Wei

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In vivo 31P magnetic resonance spectroscopy (MRS) provides a unique tool for the non-invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of 31P spectra and imaging from two distinct human brain regions of interest with dynamic B0 shimming capability. A transistor–transistor logic controller was employed to actively switch the single-channel X-nuclear radiofrequency (RF) transmitter–receiver between two 31P RF surface coils, enabling the interleaved acquisition of two 31P free induction decays (FIDs) from human occipital and frontal lobes within the same repetition time. Linear gradients were incorporated into the RF pulse sequence to perform the first-order dynamic shimming to further improve spectral resolution. The overall results demonstrate that the approach provides a cost-effective and time-efficient solution for reliable 31P MRS measurement of cerebral phosphate metabolites and adenosine triphosphate (ATP) metabolic fluxes from two human brain regions with high detection sensitivity and spectral quality at 7 T. The same design concept can be extended to acquire multiple spectra from more than two brain regions or can be employed for other magnetic resonance applications beyond the 31P spin.

AB - In vivo 31P magnetic resonance spectroscopy (MRS) provides a unique tool for the non-invasive study of brain energy metabolism and mitochondrial function. The assessment of bioenergetic impairment in different brain regions is essential to understand the pathophysiology and progression of human brain diseases. This article presents a simple and effective approach which allows the interleaved measurement of 31P spectra and imaging from two distinct human brain regions of interest with dynamic B0 shimming capability. A transistor–transistor logic controller was employed to actively switch the single-channel X-nuclear radiofrequency (RF) transmitter–receiver between two 31P RF surface coils, enabling the interleaved acquisition of two 31P free induction decays (FIDs) from human occipital and frontal lobes within the same repetition time. Linear gradients were incorporated into the RF pulse sequence to perform the first-order dynamic shimming to further improve spectral resolution. The overall results demonstrate that the approach provides a cost-effective and time-efficient solution for reliable 31P MRS measurement of cerebral phosphate metabolites and adenosine triphosphate (ATP) metabolic fluxes from two human brain regions with high detection sensitivity and spectral quality at 7 T. The same design concept can be extended to acquire multiple spectra from more than two brain regions or can be employed for other magnetic resonance applications beyond the 31P spin.

KW - dynamic B shimming

KW - high-energy phosphorus metabolism

KW - human brain

KW - in vivo P MRS imaging

KW - neuroenergetics

UR - http://www.scopus.com/inward/record.url?scp=85032282367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032282367&partnerID=8YFLogxK

U2 - 10.1002/nbm.3842

DO - 10.1002/nbm.3842

M3 - Article

C2 - 29073724

AN - SCOPUS:85032282367

VL - 31

JO - NMR in Biomedicine

JF - NMR in Biomedicine

SN - 0952-3480

IS - 1

M1 - e3842

ER -