Interictal spike analysis of high-density eeg in patients with partial epilepsy

Gang Wang, Gregory Worrell, Lin Yang, Christopher Wilke, Bin He

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Objective: The aim of this study is to investigate the use of interictal spikes to localize epileptogenic brain from noninvasive scalp EEG recordings in patients with medically intractable epilepsy. Methods: Source reconstructions were performed using a high density electrode montage and a low density electrode montage by means of a distributed source modeling method. The source of interictal spike activity was localized using both a realistic geometry boundary element method (BEM) head model and 3-shell spherical head model. Results: In the analysis of 7 patients, the high density electrode montage was found to provide results more consistent with the suspected region of epileptogenic brain identified for surgical resection using intracranial EEG recordings and structural MRI lesions, as compared to the spatial low density electrode montage used in routine clinical practice. Furthermore, the realistic geometry BEM head model provided better source localization. Conclusions: Our results indicate the merits of using high density scalp EEG recordings and realistic geometry head modeling for source localization of interictal spikes in patients with partial epilepsy. Significance: The present results suggest further improvement of source localization accuracy of epileptogenic brain from interictal EEG recorded using high density scalp electrode montage and realistic geometry head models.

Original languageEnglish (US)
Pages (from-to)1098-1105
Number of pages8
JournalClinical Neurophysiology
Issue number6
StatePublished - Jun 2011

Bibliographical note

Funding Information:
The authors would like to thank Cindy Nelson for technical assistance in data collection, and Dr. Benjamin Brinkmann for assistance in data mining. This work was supported in part by NIH RO1EB007920 , NIH RO1EB006433 , and a grant from The Minnesota Partnership for Biotechnology and Medical Genomics.


  • Boundary element method
  • EEG source localization
  • Interictal spike
  • Localization error
  • Partial epilepsy


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