Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Emily C. Baechler, Franak M. Batliwalla, George Karypis, Patrick M. Gaffney, Ward A. Ortmann, Karl J. Espe, Katherine B. Shark, William J. Grande, Karis M. Hughes, Vivek Kapur, Peter K. Gregersen, Timothy W. Behrens

Research output: Contribution to journalArticlepeer-review

1523 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is a complex, inflammatory autoimmune disease that affects multiple organ systems. We used global gene expression profiling of peripheral blood mononuclear cells to identify distinct patterns of gene expression that distinguish most SLE patients from healthy controls. Strikingly, about half of the patients studied showed dysregulated expression of genes in the IFN pathway. Furthermore, this IFN gene expression "signature" served as a marker for more severe disease involving the kidneys, hematopoetic cells, and/or the central nervous system. These results provide insights into the genetic pathways underlying SLE, and identify a subgroup of patients who may benefit from therapies targeting the IFN pathway.

Original languageEnglish (US)
Pages (from-to)2610-2615
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number5
DOIs
StatePublished - Mar 4 2003

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