Interferon- γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission

Cyrus Ayieko, Bilha S. Ogola, Lyticia Ochola, Gideon A M Ngwena, George Ayodo, James S. Hodges, Gregory S. Noland, Chandy C. John

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2 Scopus citations

Abstract

Background. Malaria elimination campaigns are planned or active in many countries. The effects of malaria elimination on immune responses such as antigen-specific IFN- γ responses are not well characterized. Methods. IFN- γ responses to the P. falciparum antigens circumsporozoite protein, liver stage antigen-1, thrombospondin-related adhesive protein, apical membrane antigen-1, MB2, and merozoite surface protein-1 were tested by ELISA in 243 individuals in highland Kenya in April 2008, October 2008, and April 2009, after a one-year period of interrupted malaria transmission from April 2007 to March 2008. Results. While one individual (0.4%) tested positive for P. falciparum byPCRinOctober 2008 and another two (0.9%) tested positive in April 2009, no clinical malaria cases were detected during weekly visits. Levels of IFN- γto all antigens decreased significantly from April 2008 to April 2009 (all P < 0.001). Discussion. Naturally acquired IFN- γ responses to P. falciparum antigensare shortlived in the absence of repeated P. falciparum infection. Even short periods of malaria interruption may significantly decrease IFN- γ responses to P. falciparum antigens.

Original languageEnglish (US)
Article numbere2855
JournalPeerJ
Volume2017
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Highland Kenya
  • Interferon gamma
  • Malaria
  • Plasmodium falciparum

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    Ayieko, C., Ogola, B. S., Ochola, L., Ngwena, G. A. M., Ayodo, G., Hodges, J. S., Noland, G. S., & John, C. C. (2017). Interferon- γ responses to Plasmodium falciparum vaccine candidate antigens decrease in the absence of malaria transmission. PeerJ, 2017(1), [e2855]. https://doi.org/10.7717/peerj.2855