Interferometric fiber-based optical biosensor to measure ultra-small changes in refractive index

Taner Akkin, Digant P. Davé, Thomas E. Milner, H. Grady Rylander

Research output: Contribution to journalConference articlepeer-review

11 Scopus citations


In many bio-medical optical imaging applications such as monitoring cell and tissue dynamics and imaging of phase objects, ultra-small changes in refractive index must be detected. We describe a fiber-based optical biosensor, which is capable of detecting ultra-small refractive index changes in highly scattering media with high lateral and longitudinal spatial resolution. The system is a dual channel phase-sensitive optical low coherence tomography system that measures relative optical path length differences between the orthogonal modes of the polarization-maintaining fiber.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2002
EventOptical Fibers and Sensors for Medical Applications II - San Jose, CA, United States
Duration: Jan 22 2002Jan 23 2002


  • Biosensor
  • Birefringence
  • Fiber
  • Interferometer
  • Phase sensitive
  • Refractive index


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