Abstract
In many bio-medical optical imaging applications such as monitoring cell and tissue dynamics and imaging of phase objects, ultra-small changes in refractive index must be detected. We describe a fiber-based optical biosensor, which is capable of detecting ultra-small refractive index changes in highly scattering media with high lateral and longitudinal spatial resolution. The system is a dual channel phase-sensitive optical low coherence tomography system that measures relative optical path length differences between the orthogonal modes of the polarization-maintaining fiber.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 9-13 |
| Number of pages | 5 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 4616 |
| DOIs | |
| State | Published - 2002 |
| Event | Optical Fibers and Sensors for Medical Applications II - San Jose, CA, United States Duration: Jan 22 2002 → Jan 23 2002 |
Keywords
- Biosensor
- Birefringence
- Fiber
- Interferometer
- Phase sensitive
- Refractive index