Interference with Fc signals increases an antibody response by T-cell-deprived cultures to a T-dependent antigen

Nicholas R St C Sinclair, Angela Panoskaltsis

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Affinity column purified goat anti-mouse immunoglobulin antibodies specific for the Fc portion of IgG increased an in vitro antibody response to a T-dependent antigen when T cells were limiting. Picogram amounts of specific anti-Fc antibody at culture initiation and nanogram quantities up to 3 days were required to demonstrate this effect. The demonstration of reconstitution by anti-Fc antibodies requires that the cultures be T-cell depleted and stimulated by antigen. These results support the concept that anti-Fc antibody and T cells block endogenously generated negative Fc signals.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalCellular Immunology
Volume107
Issue number2
DOIs
StatePublished - Jul 1987

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