Interfacial bonding in formulated bilayer tablets

Shao Yu Chang, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

To take full advantage of the drug delivery benefits offered by bilayer tablets, the common issue of weak interfacial bonding strength (IBS) with manufacturing must be overcome. This work seeks to characterize the effects of composition in individual layers and compaction pressure on the IBS. Mixtures of MCC and lactose in different ratios with and without HPMC were used where the first layer was compacted with two different pressures (20 and 100 MPa) followed by a second layer compaction pressure of 200 MPa. After identifying the failure mode as either at the interface or within a layer, the complex trends of bilayer tablet IBS as a function of MCC content were explained by considering the interplay between particle bonding strength and bonding area at the interface.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume147
DOIs
StatePublished - Feb 2020

Bibliographical note

Funding Information:
Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network, Award Number NNCI -1542202. S-Y. Chang was partially supported by a David and Marilyn Grant Fellowship in Physical Pharmacy (2017-2018), Department of Pharmaceutics, University of Minnesota.

Funding Information:
Portions of this work were conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network, Award Number NNCI -1542202 . S-Y. Chang was partially supported by a David and Marilyn Grant Fellowship in Physical Pharmacy (2017-2018), Department of Pharmaceutics, University of Minnesota.

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

  • Bilayer tablet
  • Failure mode
  • HPMC
  • Interfacial bonding strength
  • Lactose
  • Microcrystalline cellulose

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