Intercellular Conduits in Tumors: The New Social Network

Research output: Contribution to journalShort surveypeer-review

13 Scopus citations

Abstract

The role of intercellular communication is increasingly recognized as being critical to tumoral invasion, metastasis, and development of resistance to therapy. The recent discovery of cellular protrusions – tumor microtubes – connecting cancer cells in gliomas, and tunneling nanotubes in several other forms of cancer, sheds light on a novel mechanism for molecular networking. Interrupting and disrupting vital lines of intercellular crosstalk via these membranous cellular tubes has strong potential as a novel form of cancer-directed therapy.

Original languageEnglish (US)
Pages (from-to)3-5
Number of pages3
JournalTrends in Cancer
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • brain tumor networks
  • cellular protrusions
  • glioblastoma
  • intercellular communication
  • tumor microtubes
  • tunneling nanotubes

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