Intercellular adhesion molecule-1 G241R polymorphism predicts risk of incident ischemic stroke: Atherosclerosis risk in communities study

Kelly A. Volcik, Christie M. Ballantyne, Ron Hoogeveen, Aaron R. Folsom, Eric Boerwinkle

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

BACKGROUND AND PURPOSE-: Intercellular adhesion molecule-1 levels are increased in pathological studies of atherosclerosis. We evaluated 13 491 participants from the Atherosclerosis Risk in Communities Study to determine the association of intercellular adhesion molecule-1 G241R and K469E polymorphisms with incident coronary heart disease and ischemic stroke. METHODS-: Incidences of ischemic stroke (N=517) and coronary heart disease (N=1629) through 2003 were determined by annual telephone calls and hospital and death certificate surveillance. Risk factors were measured at the baseline examination. Cox proportional-hazards models were used to estimate hazard rate ratios. RESULTS-: The intercellular adhesion molecule-1 G241RR genotype was associated with a significantly increased risk of ischemic stroke in both whites (hazard rate ratio=2.18; 95% CI, 1.01 to 4.68; P=0.05) and blacks (hazard rate ratio=7.04; 95% CI, 3.72 to 13.3; P<0.001). CONCLUSIONS-: The intercellular adhesion molecule-1 241RR genotype is associated with an increased risk of incident ischemic stroke in both whites and blacks.

Original languageEnglish (US)
Pages (from-to)1038-1040
Number of pages3
JournalStroke
Volume41
Issue number5
DOIs
StatePublished - May 2010

Bibliographical note

Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.

Keywords

  • Cell adhesion molecules
  • Coronary heart disease
  • Intercellular adhesion molecule-1
  • Stroke

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