Interactive effects of race and depressive symptoms on calcification in african american and white women

Tené T. Lewis, Susan Everson-Rose, Alicia Colvin, Karen Matthews, Joyce T. Bromberger, Kim Sutton-Tyrrell

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


OBJECTIVE:: To examine the cross-sectional associations among race, depressive symptoms, and aortic and coronary calcification in a sample of middle-aged women. Depressive symptoms have been associated with atherosclerotic indicators of coronary heart disease (CHD) in white women. Few studies have examined these associations in samples including African American women, or explored whether any observed associations differ by race. METHODS:: Participants were 508 (38% African American, 62% white) women. Aortic and coronary calcification were measured by electron beam tomography and depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Multivariable linear and logistic regression models were conducted to test associations. RESULTS:: In linear regression models adjusted for race, depressive symptoms were associated with a greater amount of aortic calcification (β = 0.03, p = .01), and there was a significant race × depressive symptoms interaction (β = 0.07, p = .006). Findings for depressive symptoms (odds ratio (OR) = 1.03, 95% Confidence Interval (CI) = 1.0-1.06, p = .07), and the race × depressive symptoms interaction (OR = 1.1, 95% CI = 1.01-1.18, p = .01) were similar in race-adjusted multinomial logistic regression models predicting high levels of aortic calcification. Race-specific models revealed a significant association between depressive symptoms and aortic calcification in African American, but not white women. Additional adjustments for education, study site, and CHD risk factors did not alter these results. Depressive symptoms were not associated with coronary calcification for women of either racial group. CONCLUSIONS:: African American women may be particularly vulnerable to the effects of depressive symptoms on early atherosclerotic disease.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalPsychosomatic medicine
Issue number2
StatePublished - 2009


  • Atherosclerosis
  • Calcification
  • Coronary heart disease
  • Depressive symptoms
  • Race
  • Women


Dive into the research topics of 'Interactive effects of race and depressive symptoms on calcification in african american and white women'. Together they form a unique fingerprint.

Cite this