Interactions of Pseudorabies virus with swine alveolar macrophages I: virus replication

G. Iglesias, C. Pijoan, T. Molitor

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The replication of Pseudorabies virus (PRV) in cultured swine alveolar macrophages (AM) was studied using 6 different virus strains. AM were highly permissive to PRV infection, with progeny virus titres of 107 TCID50/ml from some strains. Virus progeny titres were higher in cultures infected with the field strains S-62 and 4892 than in cultures infected with the strains Bartha or PRV-C. Virus replication, viral DNA synthesis and the concomitant cell damage were dependent upon virus input m.o.i.s. and virus strain. Furthermore, cells from 7 day old pigs yielded higher virus progeny titres than cells of 6 week old pigs. The results from this study provide support to the premise that PRV infection may predispose anials to respiratory disease.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalArchives of Virology
Volume104
Issue number1-2
DOIs
StatePublished - Mar 1 1989

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