Interactions of bradykinin and norepinephrine on rat cutaneous nociceptors in both normal and inflamed conditions in vitro

Ratan Kumar Banik, Jun Sato, Rocio Giron, Hiroki Yajima, Kazue Mizumura

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Many inflammatory chemical mediators excite or sensitize nociceptors, which had led some researchers to believe that they may interact with each other to maintain a persistent painful state. We examined how the excitatory mediators norepinephrine (NE) and bradykinin (BK) interact, using single fiber recordings from cutaneous nociceptors. We observed that NE augmented the BK-induced response in both control and adjuvant-inflamed rats in a way different from NE-induced excitation in inflamed animals only. BK also tended to augment the NE-induced response (examined only in inflamed rats). Our results provide the first evidence that BK and NE synergistically interact on nociceptors.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalNeuroscience Research
Volume49
Issue number4
DOIs
StatePublished - Aug 1 2004

Keywords

  • Bradykinin
  • Cutaneous nociceptor
  • Inflammation
  • Norepinephrine
  • Rat

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