Interactions of bradykinin and norepinephrine on rat cutaneous nociceptors in both normal and inflamed conditions in vitro

Ratan Kumar Banik, Jun Sato, Rocio Giron, Hiroki Yajima, Kazue Mizumura

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Many inflammatory chemical mediators excite or sensitize nociceptors, which had led some researchers to believe that they may interact with each other to maintain a persistent painful state. We examined how the excitatory mediators norepinephrine (NE) and bradykinin (BK) interact, using single fiber recordings from cutaneous nociceptors. We observed that NE augmented the BK-induced response in both control and adjuvant-inflamed rats in a way different from NE-induced excitation in inflamed animals only. BK also tended to augment the NE-induced response (examined only in inflamed rats). Our results provide the first evidence that BK and NE synergistically interact on nociceptors.

Original languageEnglish (US)
Pages (from-to)421-425
Number of pages5
JournalNeuroscience Research
Volume49
Issue number4
DOIs
StatePublished - Aug 1 2004

Keywords

  • Bradykinin
  • Cutaneous nociceptor
  • Inflammation
  • Norepinephrine
  • Rat

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