Interactions between physical activity and type of cancer treatment received on associations with psychosocial outcomes among gynecologic cancer survivors

Ashley E Stenzel, Lauren Thomaier, Patricia I. Jewett, Allison C. Dona, Katherine Brown, Rachael Gotlieb, Anne Blaes, Deanna Teoh, Rachel I Vogel

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Physical activity is associated with improved cancer outcomes; however, it is unclear which patients may benefit most from increased physical activity. We evaluated whether associations between meeting the American Cancer Society (ACS) physical activity recommendations and psychosocial outcomes in gynecologic cancer survivors varied by type of treatments received. Methods: We recruited English-speaking adult gynecologic cancer patients from an academic gynecologic oncology practice to participate in a prospective cohort study. Participants completed a survey at study entry regarding their psychosocial health—including distress, depression, anxiety, post-traumatic stress disorder, and quality of life (QoL)—and physical activity. Multivariate linear regression models for each psychosocial outcome tested for interactions between physical activity and each effect modifier (receipt of chemotherapy, radiation therapy, and/or minimally invasive surgery), adjusted for age, pain, body mass index, primary cancer diagnosis, cancer stage, time since diagnosis, and annual household income. Results: Among a total of 362 participants, 213 (59%) met ACS physical activity recommendations. We found evidence of interactions between physical activity and receipt of chemotherapy for depression, anxiety, and QoL scores; those who had received chemotherapy had a stronger association between physical activity and these psychosocial outcomes, compared to those who had not. We found no evidence of interactions between physical activity and receipt of radiation therapy or minimally invasive surgery for any of the outcomes. Conclusions: Gynecologic cancer survivors who received chemotherapy had significant associations between psychosocial health and physical activity, suggesting they may derive greatest benefit from prescribed exercise.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalGynecologic oncology
Volume166
Issue number1
DOIs
StatePublished - Jul 2022

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health ( P30 CA77598 , UL1TR002494 , T32CA163184 ) and the Masonic Cancer Center . RIV is supported by a Department of Defense Ovarian Cancer Research Program Ovarian Cancer Academy Early Career Investigator Award ( OC180392 W81XWH-19-1-0013 ). The funders had no role in the implementation of this study or presentation of results.

Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

  • Cancer survivors
  • Gynecologic cancer
  • Physical activity
  • Quality of life
  • Survivorship
  • Cancer Survivors
  • Prospective Studies
  • Humans
  • Genital Neoplasms, Female/therapy
  • Quality of Life/psychology
  • Exercise
  • Adult
  • Female
  • Depression/etiology

PubMed: MeSH publication types

  • Journal Article

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