Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

Katherine R. Tonn Eisinger; Kellie S. Gross; Brian P. Head; Paul G. Mermelstein

doi:10.1016/j.yhbeh.2018.03.001

Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

Katherine R. Tonn Eisinger, Kellie S. Gross, Brian P. Head, Paul G. Mermelstein

Neuroscience

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β (ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.

Original language	English (US)
Pages (from-to)	130-137
Number of pages	8
Journal	Hormones and Behavior
Volume	104
DOIs	https://doi.org/10.1016/j.yhbeh.2018.03.001
State	Published - Aug 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

Brain
Drug addiction
Estrogen receptors
mGluR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.yhbeh.2018.03.001

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131090

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title = "Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females",

abstract = "Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β (ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.",

keywords = "Brain, Drug addiction, Estrogen receptors, mGluR",

author = "{Tonn Eisinger}, {Katherine R.} and Gross, {Kellie S.} and Head, {Brian P.} and Mermelstein, {Paul G.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = aug,

doi = "10.1016/j.yhbeh.2018.03.001",

language = "English (US)",

volume = "104",

pages = "130--137",

journal = "Hormones and Behavior",

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T1 - Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

AU - Tonn Eisinger, Katherine R.

AU - Gross, Kellie S.

AU - Head, Brian P.

AU - Mermelstein, Paul G.

PY - 2018/8

Y1 - 2018/8

N2 - Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β (ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.

AB - Contribution to Special Issue on Fast effects of steroids. Estrogen receptors α and β (ERα and ERβ) have a unique relationship with metabotropic glutamate receptors (mGluRs) in the female rodent brain such that estradiol is able to recruit intracellular G-protein signaling cascades to influence neuronal physiology, structure, and ultimately behavior. While this association between ERs and mGluRs exists in many cell types and brain regions, its effects are perhaps most striking in the nucleus accumbens (NAc). This review will discuss the original characterization of ER/mGluR signaling and how estradiol activity in the NAc confers increased sensitivity to drugs of abuse in females through this mechanism.

KW - Brain

KW - Drug addiction

KW - Estrogen receptors

KW - mGluR

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DO - 10.1016/j.yhbeh.2018.03.001

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SN - 0018-506X

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ER -

Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females

Abstract

Bibliographical note

Keywords

UN SDGs

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