TY - JOUR
T1 - Interaction of FTO and physical activity level on adiposity in african-american and European-American adults
T2 - The ARIC study
AU - Demerath, Ellen W.
AU - Lutsey, Pam L.
AU - Monda, Keri L.
AU - Linda Kao, Wen Hong
AU - Bressler, Jan
AU - Pankow, James S.
AU - North, Kari E.
AU - Folsom, Aaron R.
PY - 2011/9
Y1 - 2011/9
N2 - Physical inactivity accentuates the association of variants in the FTO locus with obesity-related traits but evidence is largely lacking in non-European populations. Here we tested the hypothesis that physical activity (PA) modifies the association of the FTO single-nucleotide polymorphism (SNP) rs9939609 with adiposity traits in 2,656 African Americans (AA) (1,626 women and 1,030 men) and 9,867 European Americans (EA) (5,286 women and 4,581 men) aged 45-66 years in the Atherosclerosis Risk in Communities (ARIC) study. Individuals in the lowest quintile of the sport activity index of the Baecke questionnaire were categorized as low PA. Baseline BMI, waist circumference (WC), and skinfold measures were dependent variables in regression models testing the additive effect of the SNP, low PA, and their interaction, adjusting for age, alcohol use, cigarette use, educational attainment, and percent European ancestry in AA adults, stratified by sex and race/ethnicity. rs9939609 was associated with adiposity in all groups other than AA women. The SNP × PA interaction was significant in AA men (P<0.002 for all traits) and EA men (P<0.04 for all traits). For each additional copy of the A (risk) allele, WC in AA men was higher in those with low PA (ΒlowPA: 5.1cm, 95% confidence interval (CI): 2.6-7.5) than high PA (ΒhighPA: 0.7cm, 95% CI: 0.4 to 1.9); P (interaction) = 0.002). The interaction effect was not observed in EA or AA women. FTO SNP × PA interactions on adiposity were observed for AA as well as EA men. Differences by sex require further examination.
AB - Physical inactivity accentuates the association of variants in the FTO locus with obesity-related traits but evidence is largely lacking in non-European populations. Here we tested the hypothesis that physical activity (PA) modifies the association of the FTO single-nucleotide polymorphism (SNP) rs9939609 with adiposity traits in 2,656 African Americans (AA) (1,626 women and 1,030 men) and 9,867 European Americans (EA) (5,286 women and 4,581 men) aged 45-66 years in the Atherosclerosis Risk in Communities (ARIC) study. Individuals in the lowest quintile of the sport activity index of the Baecke questionnaire were categorized as low PA. Baseline BMI, waist circumference (WC), and skinfold measures were dependent variables in regression models testing the additive effect of the SNP, low PA, and their interaction, adjusting for age, alcohol use, cigarette use, educational attainment, and percent European ancestry in AA adults, stratified by sex and race/ethnicity. rs9939609 was associated with adiposity in all groups other than AA women. The SNP × PA interaction was significant in AA men (P<0.002 for all traits) and EA men (P<0.04 for all traits). For each additional copy of the A (risk) allele, WC in AA men was higher in those with low PA (ΒlowPA: 5.1cm, 95% confidence interval (CI): 2.6-7.5) than high PA (ΒhighPA: 0.7cm, 95% CI: 0.4 to 1.9); P (interaction) = 0.002). The interaction effect was not observed in EA or AA women. FTO SNP × PA interactions on adiposity were observed for AA as well as EA men. Differences by sex require further examination.
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U2 - 10.1038/oby.2011.131
DO - 10.1038/oby.2011.131
M3 - Article
C2 - 21593801
AN - SCOPUS:80052160447
SN - 1930-7381
VL - 19
SP - 1866
EP - 1872
JO - Obesity
JF - Obesity
IS - 9
ER -