Abstract
The possible role of dynorphin in the control of gut function was explored using longitudinal muscle-myenteric plexus preparations of the guinea pig ileum. Dynorphin-(1-130 as well as other endorphins, μ or k opioid alkaloids antagonized in a dose-dependent fashion the isometric contractions caused by neurotensin. Ethylketocyclazocine and dynorphin-(1-13) were found to be potent inhibitors of the neurotensin-induced excitatory response, having IC50s of about 1 and 5 nM respectively; ketocyclazocine, normorphine and leucine enkephalin also inhibited the contractile effect of neurotensin but at concentrations 2, 30 and 400 times that of dynorphin (1-13).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1825-1828 |
| Number of pages | 4 |
| Journal | Life Sciences |
| Volume | 31 |
| Issue number | 16-17 |
| DOIs | |
| State | Published - 1982 |
Bibliographical note
Funding Information:This investigation was partially supported by NIDA grants DA 01696 and DA 00037. Y.X. Zhu is a visiting scholar from the People's Republic of China with a fellowship from the World Health Organization. We thank Dr. E.T. lwamoto for the samples of ketocyclazoclnes. Also we wish to thank L'Inglessina Carnes for secretarial assistance.