Interaction of β-blockers and angiotensin receptor blockers/ACE inhibitors in heart failure

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The renin-angiotensin-aldosterone system contributes to the progression of heart failure and its inhibition slows ventricular remodelling and favourably affects morbidity and mortality. β-blockers exert a remarkably favourable effect on progression that may be mediated at least in part by renin inhibition. Although earlier trials suggested a possible adverse interaction when an angiotensin receptor blocker was added to an angiotensin-converting enzyme inhibitor and a β-blocker, a recent study and newly analysed mechanistic data indicate that the triple combination provides modest additional inhibition of angiotensin that can further slow progression of disease.

Original languageEnglish (US)
Pages (from-to)137-139
Number of pages3
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume4
Issue number3
DOIs
StatePublished - Jan 1 2003

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Ventricular Remodeling
Angiotensin Receptor Antagonists
Angiotensins
Renin-Angiotensin System
Angiotensin-Converting Enzyme Inhibitors
Renin
Disease Progression
Heart Failure
Morbidity
Mortality

Keywords

  • ACE inhibitors
  • Angiotensin
  • Morbidity
  • Mortality
  • β-blockers

Cite this

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AB - The renin-angiotensin-aldosterone system contributes to the progression of heart failure and its inhibition slows ventricular remodelling and favourably affects morbidity and mortality. β-blockers exert a remarkably favourable effect on progression that may be mediated at least in part by renin inhibition. Although earlier trials suggested a possible adverse interaction when an angiotensin receptor blocker was added to an angiotensin-converting enzyme inhibitor and a β-blocker, a recent study and newly analysed mechanistic data indicate that the triple combination provides modest additional inhibition of angiotensin that can further slow progression of disease.

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