Interaction between two essential, conserved bacterial proteins YeaZ and glycoprotease as a potential antibacterial target in multi-drug-resistant Staphylococcus aureus

Timmie A. Britton, Haiyong Guo, Yinduo Ji

Research output: Contribution to journalReview article

Abstract

Protein–protein interactions among highly conserved and essential proteins can serve as new targets for antibacterial therapies. One protein–protein interaction between two widely conserved and essential bacterial proteins, YeaZ and its paralog, a putative glycoprotease, is being looked into for its antimicrobial drug potential. These two proteins possess tandem functions, including repression of the branched-chain amino acids biosynthesis and induction of a tRNA modification important in enhancing translation fidelity through anticodon–codon base pairing. Heterodimer formation between these two proteins is essential for Staphylococcus aureus, and other bacterial species including Escherichia coli and Salmonella typhimurium. Such YeaZ–glycoprotease interaction could thus be a target for antimicrobial drugs designed for multi-drug-resistant S. aureus. In this review, we discuss the function, structure, and interaction between these two proteins and their orthologs in other bacteria.

Original languageEnglish (US)
JournalScience Progress
Volume103
Issue number1
DOIs
StatePublished - Jan 1 2020

Keywords

  • Staphylococcus aureus
  • YeaZ
  • antibacterial target
  • glycoprotease
  • protein–protein interaction

PubMed: MeSH publication types

  • Journal Article

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