Intensive care and emergency medicine: Progress over the past 25 years

Jean Louis Vincent, Mitchell P. Fink, John J. Marini, Michael R. Pinsky, William J. Sibbald, Mervyn Singer, Peter M. Suter, Deborah Cook, Paul E. Pepe, Timothy Evans

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Over the last quarter of a century, intensive care medicine has developed into an established hospital specially with its own unique identity and characteristics. Significant advances have occurred, mostly in a succession of small steps rather than any dramatic leap, with many being linked to advances in health care across other disciplines. In addition, many changes have resulted from the scientific identification of the detrimental effects of certain traditional practices once thought to be therapeutic. Here, in an attempt to learn from the past and offer guidance for future progress, we detail some of the key changes in various aspects of intensive care medicine including respiratory, cardiovascular, metabolic, and nutritional care, as well as sepsis, polytrauma, organization, and management.

Original languageEnglish (US)
Pages (from-to)1061-1067
Number of pages7
Issue number4
StatePublished - Apr 2006

Bibliographical note

Funding Information:
The following authors have indicated to the American College of Chest Physicians that no significant relationships exist with any company/organization whose products or services may be discussed in this article submission: Michael R. Pinsky, MD; Jean-Louis Vincent, MD; Timothy W. Evans, MD; John J. Marini, MD; Peter Suter, MD; Deborah Cook, MD; and Paul Pepe, MD. The following authors have disclosed financial relationships with a commercial party (grant information and company names appear as provided): Mervyn Singer, MD: UK Department of Health: Grant Deltex: Unrestricted Educational Grant. Mitchell Fink, MD: Defense Advanced Research Projects Agency (DARPA): Grant National Institutes of Health (NIH): Grant Critical Therapeutics, Inc.: Consultant; NovoNordisk: Consultant; Inotek Pharmaceuticals, Inc.: Fiduciary Position; Midway Pharmaceuticals, Inc.: Fiduciary Position. William Sibbald, MD: Canadian Institute of Health Research: Grant; Heart and Stroke Foundation of Canada: Grant.


  • ARDS
  • Cardiopulmonary resuscitation
  • Cardiovascular care
  • Critical care
  • Intensive care
  • Mechanical ventilation
  • Multiorgan failure
  • Polytrauma
  • Sepsis
  • invasive monitoring


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