Integrins and T cell-mediated immunity

Jonathan T. Pribila, Angie C. Quale, Kristen L. Mueller, Yoji Shimizu

Research output: Contribution to journalReview article

172 Citations (Scopus)

Abstract

Integrin receptors mediate adhesive events that are critical for a specific and effective immune response to foreign pathogens. Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue. Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-specific interactions between T lymphocytes and APCs that are critical for initiating T cell-activation events. In this review, we discuss the role of integrins in T cell-mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs.

Original languageEnglish (US)
Pages (from-to)157-180
Number of pages24
JournalAnnual Review of Immunology
Volume22
DOIs
StatePublished - Jun 7 2004

Fingerprint

Integrins
Cellular Immunity
T-Lymphocytes
Antigen-Presenting Cells
Viral Tumor Antigens
CD27 Antigens
Lymphocytes
Adhesives
Endothelium
Cell Movement
Extracellular Matrix
Antigens

Keywords

  • Chemokine
  • Dendritic cell
  • Extracellular matrix
  • Immunological synapse
  • Signal transduction

Cite this

Integrins and T cell-mediated immunity. / Pribila, Jonathan T.; Quale, Angie C.; Mueller, Kristen L.; Shimizu, Yoji.

In: Annual Review of Immunology, Vol. 22, 07.06.2004, p. 157-180.

Research output: Contribution to journalReview article

Pribila, Jonathan T. ; Quale, Angie C. ; Mueller, Kristen L. ; Shimizu, Yoji. / Integrins and T cell-mediated immunity. In: Annual Review of Immunology. 2004 ; Vol. 22. pp. 157-180.
@article{18d0089087d848c2a90dd0918503ba37,
title = "Integrins and T cell-mediated immunity",
abstract = "Integrin receptors mediate adhesive events that are critical for a specific and effective immune response to foreign pathogens. Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue. Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-specific interactions between T lymphocytes and APCs that are critical for initiating T cell-activation events. In this review, we discuss the role of integrins in T cell-mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs.",
keywords = "Chemokine, Dendritic cell, Extracellular matrix, Immunological synapse, Signal transduction",
author = "Pribila, {Jonathan T.} and Quale, {Angie C.} and Mueller, {Kristen L.} and Yoji Shimizu",
year = "2004",
month = "6",
day = "7",
doi = "10.1146/annurev.immunol.22.012703.104649",
language = "English (US)",
volume = "22",
pages = "157--180",
journal = "Annual Review of Immunology",
issn = "0732-0582",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Integrins and T cell-mediated immunity

AU - Pribila, Jonathan T.

AU - Quale, Angie C.

AU - Mueller, Kristen L.

AU - Shimizu, Yoji

PY - 2004/6/7

Y1 - 2004/6/7

N2 - Integrin receptors mediate adhesive events that are critical for a specific and effective immune response to foreign pathogens. Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue. Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-specific interactions between T lymphocytes and APCs that are critical for initiating T cell-activation events. In this review, we discuss the role of integrins in T cell-mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs.

AB - Integrin receptors mediate adhesive events that are critical for a specific and effective immune response to foreign pathogens. Integrin-dependent interactions of lymphocytes and antigen-presenting cells (APCs) to endothelium regulate the efficiency and specificity of trafficking into secondary lymphoid organs and peripheral tissue. Within these sites, integrins facilitate cell movement via interactions with the extracellular matrix, and promote and stabilize antigen-specific interactions between T lymphocytes and APCs that are critical for initiating T cell-activation events. In this review, we discuss the role of integrins in T cell-mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs.

KW - Chemokine

KW - Dendritic cell

KW - Extracellular matrix

KW - Immunological synapse

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=2542504572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542504572&partnerID=8YFLogxK

U2 - 10.1146/annurev.immunol.22.012703.104649

DO - 10.1146/annurev.immunol.22.012703.104649

M3 - Review article

C2 - 15032577

AN - SCOPUS:2542504572

VL - 22

SP - 157

EP - 180

JO - Annual Review of Immunology

JF - Annual Review of Immunology

SN - 0732-0582

ER -