Integrin function in T-Cell homing to lymphoid and nonlymphoid sites: Getting there and staying there

Christopher C. Denucci, Jason S. Mitchell, Yoji Shimizu

Research output: Contribution to journalReview articlepeer-review

101 Scopus citations


The continuous recirculation of naive T cells and their subsequent migration to tissue following activation is crucial for maintaining protective immunity against invading pathogens. The preferential targeting of effector and memory T cells to tissue is instructed during priming and mediated by cell surface expressed adhesion receptors such as integrins. Integrins arc involved in nearly all aspects of T-cell life, including naive T-cell circulation, activation, and finally effector T-cell trafficking and localization. Recent research has revealed that microenvironmental factors present during T-cell priming result in the specific regulation of adhesion/integrin and chemokine receptor expression. Once antigen-experienced T cells enter tissue, further changes in integrin expression may occur that arc critical for T-cell localization, retention, effector function, and survival. This review discusses the function of integrin expression on T cells and the multiple roles integrins play on naive T cells and in directing effector T-cell trafficking to nonlymphoid sites in order to maintain protective adaptive immunity at body barriers.

Original languageEnglish (US)
Pages (from-to)87-109
Number of pages23
JournalCritical Reviews in Immunology
Issue number2
StatePublished - 2009


  • Adhesion
  • Integrin
  • Lymphocyte
  • Retention
  • Trafficking


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