Integration of nanoassembly functions for an effective delivery cascade for cancer drugs

Qihang Sun, Xuanrong Sun, Xinpeng Ma, Zhuxian Zhou, Erlei Jin, Bo Zhang, Youqing Shen, Edward A. Van Kirk, William J. Murdoch, Joseph R. Lott, Timothy P. Lodge, Maciej Radosz, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

205 Scopus citations

Abstract

A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release. (Figure Presented).

Original languageEnglish (US)
Pages (from-to)7615-7621
Number of pages7
JournalAdvanced Materials
Volume26
Issue number45
DOIs
StatePublished - Dec 3 2014

Keywords

  • Biomedical applications
  • Dendrimers
  • Drug delivery
  • Lipids
  • Nanomedicine
  • Self-assembly

Fingerprint Dive into the research topics of 'Integration of nanoassembly functions for an effective delivery cascade for cancer drugs'. Together they form a unique fingerprint.

Cite this