Integrating tumor genomics into studies of the microbiome in colorectal cancer

Michael B. Burns, Ran Blekhman

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Although the gut microbiome has been linked to colorectal cancer (CRC) development, associations of microbial taxa with CRC status are often inconsistent across studies. We have recently shown that tumor genomics, a factor that is rarely incorporated in analyses of the CRC microbiome, has a strong effect on the composition of the microbiota. Here, we discuss these results in the wider context of studies characterizing interaction between host genetics and the microbiome, and describe the implications of our findings for understanding the role of the microbiome in CRC.

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalGut microbes
Volume10
Issue number4
DOIs
StatePublished - Jan 1 2019

Keywords

  • Microbiome
  • colorectal cancer
  • tumor genomics

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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