Integrating hippocampus and striatum in decision-making

Adam Johnson, Matthijs AA van der Meer, A. David Redish

    Research output: Contribution to journalReview article

    176 Scopus citations

    Abstract

    Learning and memory and navigation literatures emphasize interactions between multiple memory systems: a flexible, planning-based system and a rigid, cached-value system. This has profound implications for decision-making. Recent conceptualizations of flexible decision-making employ prospection and projection arising from a network involving the hippocampus. Recent recordings from rodent hippocampus in decision-making situations have found transient forward-shifted representations. Evaluation of that prediction and subsequent action-selection probably occurs downstream (e.g. in orbitofrontal cortex, in ventral and dorsomedial striatum). Classically, striatum has been identified as a crucial component of the less-flexible, incremental system. Current evidence, however, suggests that striatum is involved in both flexible and stimulus-response decision-making, with dorsolateral striatum involved in stimulus-response strategies and ventral and dorsomedial striatum involved in goal-directed strategies.

    Original languageEnglish (US)
    Pages (from-to)692-697
    Number of pages6
    JournalCurrent opinion in neurobiology
    Volume17
    Issue number6
    DOIs
    StatePublished - Dec 2007

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