Intake of fruit juice and incidence of type 2 diabetes: A systematic review and meta-analysis

Bo Xi, Shuangshuang Li, Zhaolu Liu, Huan Tian, Xiuxiu Yin, Pengcheng Huai, Weihong Tang, Donghao Zhou, Lyn M. Steffen

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

Background: Several prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. In the present study, we aimed to estimate the association between fruit juice intake and risk of type 2 diabetes. Methods: PubMed and Embase databases were searched up to December 2013. All prospective cohort studies of fruit juice intake with risk of type 2 diabetes were included. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for highest vs. lowest category of fruit juice intake were estimated using a random-effects model. Results: A total of four studies (191,686 participants, including 12,375 with type 2 diabetes) investigated the association between sugar-sweetened fruit juice and risk of incident type 2 diabetes, and four studies (137,663 participants and 4,906 cases) investigated the association between 100% fruit juice and risk of incident type 2 diabetes. A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes (RR = 1.28, 95%CI = 1.04-1.59, p = 0.02), while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes (RR = 1.03, 95% CI = 0.91-1.18, p = 0.62). Conclusions: Our findings support dietary recommendations to limit sugar-sweetened beverages, such as fruit juice with added sugar, to prevent the development of type 2 diabetes.

Original languageEnglish (US)
Article numbere93471
JournalPloS one
Volume9
Issue number3
DOIs
StatePublished - Mar 28 2014

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